Extracellular Vesicles (EVs) and Pancreatic Cancer: From the Role of EVs to the Interference with EV-Mediated Reciprocal Communication

Biomedicines

HanYeoung Lee¹  SooYoung Choi¹  TaeHee Kim¹  Sokviseth Moeng¹  SeungWan Son¹  JongKook Park¹  JongSun Lee¹  HyoJeong Kuh² 

[1] Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea;Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea;

关键词: extracellular vesicles;    exosomes;    microvesicles;    microenvironment;    non-coding RNA;    pancreatic cancer;   

DOI  :  10.3390/biomedicines8080267

来源: DOAJ

【 摘 要 】

Pancreatic cancer is malignant and the seventh leading cause of cancer-related deaths worldwide. However, chemotherapy and radiotherapy are—at most—moderately effective, indicating the need for new and different kinds of therapies to manage this disease. It has been proposed that the biologic properties of pancreatic cancer cells are finely tuned by the dynamic microenvironment, which includes extracellular matrix, cancer-associated cells, and diverse immune cells. Accumulating evidence has demonstrated that extracellular vesicles (EVs) play an essential role in communication between heterogeneous subpopulations of cells by transmitting multiplex biomolecules. EV-mediated cell–cell communication ultimately contributes to several aspects of pancreatic cancer, such as growth, angiogenesis, metastasis and therapeutic resistance. In this review, we discuss the role of extracellular vesicles and their cargo molecules in pancreatic cancer. We also present the feasibility of the inhibition of extracellular biosynthesis and their itinerary (release and uptake) for a new attractive therapeutic strategy against pancreatic cancer.

【 授权许可】

Unknown