Is PML a tumor suppressor?

Frontiers in Oncology

Massimiliano eMazza¹  Pier Giuseppe ePelicci¹ 

[1]European Institute of Oncology (IEO)

关键词: Cancer;    cancer therapy;    tumor suppressor;    cancer stem cells (CSC);    PML;   

DOI  :  10.3389/fonc.2013.00174

来源: DOAJ

【 摘 要 】

The role of the promyelocytic leukemia protein (PML) has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.

【 授权许可】

Unknown