Autophagy regulation in cancer development and therapy

American Journal of Cancer Research

Vanesa Martin¹  Sarah R Klein¹  Sujan Piya¹  Candelaria Gomez-Manzano¹  Juinn-Lin Liu¹  Juan Fueyo¹  Erin J White¹  Hong Jiang¹ 

关键词: Autophagy;    tumor suppressor;    oncogene;    cancer;    cancer therapy;    PTEN;    p53;    RB;    E2F1;    Bcl-2;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Autophagy is a cellular process to degrade long-lived or malfunctioning proteins and obsolete or damaged organelles. It maintains cellular homeostasis and helps cells survive stressful conditions. Tumor suppressors mostly positively regulate autophagy, whereas oncogene products usually inhibit autophagy. Alterations in key autophagy genes have also been shown to affect cancer development. However, the role of autophagy in cancer depends on the status of the cells and can either suppress or promote tumor growth. In the present review, we report on the current state of knowledge about the reciprocal regulation of autophagy and the potential role of autophagy played in cancer development and therapy.

【 授权许可】

Unknown