Association between the microbiota and women’s cancers – Cause or consequences?

Biomedicine & Pharmacotherapy

Adele Balouchi¹  Gordon A. Ferns²  Mojgan Esparvarinha³  Negin Alizadehmohajer⁴  Mostafa Manian⁴  Samaneh Shojaeifar⁵  Forogh Mohammadi⁶  Majid Ghayour-Mobarhan⁷  Reza Nedaeinia⁸ 

[1] Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran;Brighton and Sussex Medical School, Division of Medical Education, Falmer, Brighton, Sussex BN1 9PH, UK;Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Medical Laboratory Science, Faculty of Medicine, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran;Department of Midwifery, Faculty of Nursing and Midwifery, Arak University of Medical Sciences, Arak, Iran;Department of Veterinary, Agriculture Faculty, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran;Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;

关键词: Bacterial microbiota;    DNA damage;    Dysbiosis mechanisms;    Women’s cancers;   

DOI  :  

来源: DOAJ

【 摘 要 】

Breast, ovarian and uterine cancers are the most common neoplasms among women. Several mechanisms may be involved in oncogenesis and these include environmental and genetic factors. Bacteria may affect the development of some cancers, with bacterial components, their products and metabolites interacting with susceptible tissues. Commensalism and dysbiosis are important potential mechanisms involved in oncogenesis, and an effective strategy for diagnosis and treatment is required. The purpose of this review was to analyze the complex associations between these cancers in women, and the microbiota, specifically bacterial microbes. However, several cancers have an increased prevalence among individuals with HIV and HPV so the relationship between viral infections and malignancies in women is also referred to. We described how different phylum of bacteria, particularly in the gut, mammary tissue and vaginal microbiome may be involved in carcinogenesis; and we discuss the potential pathways involved: (I), that lead to cell proliferation, (II), immune system perturbation, (III), cell metabolic changes (e.g., hormonal factors), and (IV), DNA damage. Studies investigating the differences between the composition of the bacterial microbiota of healthy women compared to that present in various conditions, and the clinical trials are summarized for the few studies that have addressed the microbiota and related conditions, are also reviewed.

【 授权许可】

Unknown