XRCC1 Arg399Gln was associated with repair capacity for DNA damage induced by occupational chromium exposure

BMC Research Notes

Yimin Zhu⁴  Hong Fu³  Jingmin Yu²  Zhangping Yang¹  Qing Chen⁵  Lei Zhang¹  Xuan Zhang⁵  Xuhui Zhang¹ 

[1] Hangzhou Center for Disease Control and Prevention, Hangzhou 310021, People's Republic of China;Tonglu Center for Disease Control and prevention, Tonglu 311500, People's Republic of China;Jiande Center for Disease Control and prevention, Jiande 311600, People's Republic of China;Department of Epidemiology and Biostatistics, Zhejiang University School of Medicine, 388 Yu-Hang-Tang Road, Hangzhou 310058, Zhejiang, People's Republic of China;Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, People's Republic of China

关键词: Occupational chromium exposure;    XRCC1;    Genetic susceptibility;    DNA damage;   

Others  :  1166380
DOI  :  10.1186/1756-0500-5-263

 received in 2011-07-14, accepted in 2012-05-15,  发布年份 2012

【 摘 要 】

Background

Occupational chromium exposure may induce DNA damage and lead to lung cancer and other work-related diseases. DNA repair gene polymorphisms, which may alter the efficiency of DNA repair, thus may contribute to genetic susceptibility of DNA damage. The aim of this study was to test the hypothesis that the genetic variations of 9 major DNA repair genes could modulate the hexavalent chromium (Cr (VI))-induced DNA damage.

Findings

The median (P₂₅-P₇₅) of Olive tail moment was 0.93 (0.58–1.79) for individuals carrying GG genotype of XRCC1 Arg399Gln (G/A), 0.73 (0.46–1.35) for GA heterozygote and 0.50 (0.43–0.93) for AA genotype. Significant difference was found among the subjects with three different genotypes (P = 0.048) after adjusting the confounding factors. The median of Olive tail moment of the subjects carrying A allele (the genotypes of AA and GA) was 0.66 (0.44–1.31), which was significantly lower than that of subjects with GG genotype (P = 0.043). The A allele conferred a significantly reduced risk of DNA damage with the OR of 0.39 (95% CI: 0.15–0.99, P = 0.048). No significant association was found between the XRCC1Arg194Trp, ERCC1 C8092A, ERCC5 His1104Asp, ERCC6 Gly399Asp, GSTP1 Ile105Val, OGG1 Ser326Cys, XPC Lys939Gln, XPD Lys751Gln and DNA damage.

Conclusion

The polymorphism of Arg399Gln in XRCC1 was associated with the Cr (VI)- induced DNA damage. XRCC1 Arg399Gln may serve as a genetic biomarker of susceptibility for Cr (VI)- induced DNA damage.

【 授权许可】

   
2012 Zhang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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