The protective effects of liguzinediol on congestive heart failure induced by myocardial infarction and its relative mechanism

Chinese Medicine

Dini Zhang¹  Yu Li²  Qinghai Meng³  Yunhui Bi³  Weiwei Zhang³  Huimin Bian³  Yuhan Zhang³  Qi Chen³ 

[1] Key Laboratory on Biosafety, Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment;School of Medicine and Life Sciences, Nanjing University of Chinese Medicine;School of Pharmacy, Nanjing University of Chinese Medicine;

关键词: Liguzinediol;    Heart failure;    Myocardial infraction;    TGF-β1/Smads;   

DOI  :  10.1186/s13020-020-00345-7

来源: DOAJ

【 摘 要 】

Abstract Background Heart failure (HF) is one of the most common causes of cardiovascular diseases in the world. Currently, the drugs used to treat HF in the clinic may cause serious side effects. Liguzinediol, 2, 5-dimethyl-3, 6-dimethyl-pyrazine, is a compound synthesized after the structural modification of ligustrazine (one active ingredient of Szechwan Lovage Rhizome). We aimed to observe the effects of liguzinediol on preventing HF and explore the related mechanisms. Methods The ligation of left anterior descending coronary artery was operated to established the myocardial infarction (MI) model in Sprague–Dawley rats. Cardiac functions were recorded by echocardiography and hemodynamics. The changes in the Renin–Angiotensin–Aldosterone System (RAAS), inflammation, and oxidative stress were detected by radioimmunoassay and Elisa kits. Western blot and real-time PCR were applied to determine the expressions of the TGF-β1/Smads pathway. Results Firstly, liguzinediol enhanced the systolic and diastolic functions of the heart in MI rats. Liguzinediol improved ventricular remodeling by reducing myocardial cell necrosis, as well as reducing collagen deposition and myocardial fibrosis. Then, liguzinediol suppressed the activation of RAAS, inhibited the synthesis of pro-inflammation factors, and reduced oxidative stress. In the end, liguzinediol also down-regulated the expressions of the TGF-β1/Smads pathway. Conclusions Liguzinediol could alleviate HF caused by MI in rats, and the protective effect was associated with the regulation of the TGF-β1/Smads pathway.

【 授权许可】

Unknown