期刊论文详细信息
Frontiers in Chemistry | |
Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes | |
Christine J. Cardin1  Sarah P. Gurung2  Kane McQuaid2  James P. Hall2  John A. Brazier3  Benjamin J. Pages3  | |
[1] Department of Chemistry, University of Reading, Reading, United Kingdom;Diamond Light Source, Didcot, United Kingdom;School of Pharmacy, University of Reading, Reading, United Kingdom; | |
关键词: i-motif; DNA; ruthenium; melting; stabilization; luminescence; | |
DOI : 10.3389/fchem.2019.00744 | |
来源: DOAJ |
【 摘 要 】
A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.
【 授权许可】
Unknown