Stabilization of Long-Looped i-Motif DNA by Polypyridyl Ruthenium Complexes

Frontiers in Chemistry

Christine J. Cardin¹  Sarah P. Gurung²  Kane McQuaid²  James P. Hall²  John A. Brazier³  Benjamin J. Pages³ 

[1] Department of Chemistry, University of Reading, Reading, United Kingdom;Diamond Light Source, Didcot, United Kingdom;School of Pharmacy, University of Reading, Reading, United Kingdom;

关键词: i-motif;    DNA;    ruthenium;    melting;    stabilization;    luminescence;   

DOI  :  10.3389/fchem.2019.00744

来源: DOAJ

【 摘 要 】

A spectroscopic study of the interactions of Λ- and Δ-[Ru(phen)2(dppz)]2+ with i-motif DNA containing thymine loops of various lengths. In the presence of i-motifs, the luminescence of the Λ enantiomer was enhanced much more than the Δ. Despite this, the effect of each enantiomer on i-motif thermal stability was comparable. The sequences most affected by [Ru(phen)2(dppz)]2+ were those with long thymine loops; this suggests that long-looped i-motifs are attractive targets for potential transition metal complex drugs and should be explored further in drug design.

【 授权许可】

Unknown