Association Between the Gut Microbiota and Blood Pressure in a Population Cohort of 6953 Individuals

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Michael Inouye¹  Leo Lahti²  Aaro Salosensaari³  Teemu J. Niiranen³  Joonatan Palmu³  Rob Knight⁴  Rodolfo A. Salido⁴  Caitriona Brennan⁴  Jon G. Sanders⁴  Gregory C. Humphrey⁴  Karenina Sanders⁴  Veikko Salomaa⁵  Erkki Vartiainen⁵  Aki S. Havulinna⁵  Tiina Laatikainen⁵  Pekka Jousilahti⁵  Mohit Jain⁶  Susan Cheng⁷ 

[1] Cambridge Baker Systems Genomics Initiative Baker Heart and Diabetes Institute Melbourne Australia;Department of Future Technologies University of Turku Finland;Department of Medicine Turku University Hospital and University of Turku Finland;Department of Pediatrics University of California, San Diego CA;Department of Public Health Solutions Finnish Institute for Health and Welfare Helsinki Finland;Departments of Medicine and Pharmacology University of California, San Diego San Diego CA;Division of Cardiology Brigham and Women’s Hospital Boston MA;

关键词: blood pressure;    gastrointestinal microbiota;    hypertension;    Lactobacillus;    salt intake;   

DOI  :  10.1161/JAHA.120.016641

来源: DOAJ

【 摘 要 】

Background Several small‐scale animal studies have suggested that gut microbiota and blood pressure (BP) are linked. However, results from human studies remain scarce and conflicting. We wanted to elucidate the multivariable‐adjusted association between gut metagenome and BP in a large, representative, well‐phenotyped population sample. We performed a focused analysis to examine the previously reported inverse associations between sodium intake and Lactobacillus abundance and between Lactobacillus abundance and BP. Methods and Results We studied a population sample of 6953 Finns aged 25 to 74 years (mean age, 49.2±12.9 years; 54.9% women). The participants underwent a health examination, which included BP measurement, stool collection, and 24‐hour urine sampling (N=829). Gut microbiota was analyzed using shallow shotgun metagenome sequencing. In age‐ and sex‐adjusted models, the α (within‐sample) and β (between‐sample) diversities of taxonomic composition were strongly related to BP indexes (P<0.001 for most). In multivariable‐adjusted models, β diversity was only associated with diastolic BP (P=0.032). However, we observed significant, mainly positive, associations between BP indexes and 45 microbial genera (P<0.05), of which 27 belong to the phylum Firmicutes. Interestingly, we found mostly negative associations between 19 distinct Lactobacillus species and BP indexes (P<0.05). Of these, greater abundance of the known probiotic Lactobacillus paracasei was associated with lower mean arterial pressure and lower dietary sodium intake (P<0.001 for both). Conclusions Although the associations between overall gut taxonomic composition and BP are weak, individuals with hypertension demonstrate changes in several genera. We demonstrate strong negative associations of certain Lactobacillus species with sodium intake and BP, highlighting the need for experimental studies.

【 授权许可】

Unknown