Biological Factors, Metals, and Biomaterials Regulating Osteogenesis through Autophagy

International Journal of Molecular Sciences

Silvia Sancilio¹  Amelia Cataldi²  Viviana di Giacomo² 

[1] Department of Medicine and Ageing Sciences, University “G. d’Annunzio”, 66100 Chieti-Pescara, Italy;Department of Pharmacy, University “G. d’Annunzio”, 66100 Chieti-Pescara, Italy;

关键词: autophagy;    osteogenesis;    bone regeneration;    osteoclastogenesis;    biomaterial;    osteoclast;   

DOI  :  10.3390/ijms21082789

来源: DOAJ

【 摘 要 】

Bone loss raises great concern in numerous situations, such as ageing and many diseases and in both orthopedic and dentistry fields of application, with an extensive impact on health care. Therefore, it is crucial to understand the mechanisms and the determinants that can regulate osteogenesis and ensure bone balance. Autophagy is a well conserved lysosomal degradation pathway, which is known to be highly active during differentiation and development. This review provides a revision of the literature on all the exogen factors that can modulate osteogenesis through autophagy regulation. Metal ion exposition, mechanical stimuli, and biological factors, including hormones, nutrients, and metabolic conditions, were taken into consideration for their ability to tune osteogenic differentiation through autophagy. In addition, an exhaustive overview of biomaterials, both for orthopedic and dentistry applications, enhancing osteogenesis by modulation of the autophagic process is provided as well. Already investigated conditions regulating bone regeneration via autophagy need to be better understood for finely tailoring innovative therapeutic treatments and designing novel biomaterials.

【 授权许可】

Unknown