MicroRNAs Regulate Bone Development and Regeneration

International Journal of Molecular Sciences

Sijie Fang²  Yuan Deng²  Ping Gu²  Xianqun Fan¹ 

[1] Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, China;

关键词: microRNA;    osteogenesis;    bone regeneration;   

DOI  :  10.3390/ijms16048227

来源: mdpi

【 摘 要 】

MicroRNAs (miRNAs) are endogenous small noncoding ~22-nt RNAs, which have been reported to play a crucial role in maintaining bone development and metabolism. Osteogenesis originates from mesenchymal stem cells (MSCs) differentiating into mature osteoblasts and each period of bone formation is inseparable from the delicate regulation of various miRNAs. Of note, apprehending the sophisticated circuit between miRNAs and osteogenic homeostasis is of great value for artificial skeletal regeneration for severe bone defects. In this review, we highlight how different miRNAs interact with diverse osteo-related genes and endeavor to sketch the contours of potential manipulations of miRNA-modulated bone repair.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.