BMP9 signaling in stem cell differentiation and osteogenesis

American Journal of Stem Cells

Yuhan Kong¹  Rex C Haydon¹  Xing Liu¹  Guoxin Nan¹  Ruidong Li¹  Jiaqiang Qin¹  Wenwen Zhang¹  Mary Rose Rogers¹  Sahitya Denduluri¹  Hue H Luu¹  Jinhua Wang¹  Hongyu Zhang¹  Abdullah Pratt¹  Jiye Zhang¹  Lewis L Shi¹  Justin Tomal¹  Joseph D Lamplot¹  Jovito Angeles¹  Liangjun Yin¹  Wei Shui¹  Tong-Chuan He¹  Stephanie H Kim¹ 

关键词: BMP;    BMP9;    bone regeneration;    IGF;    osteogenesis;    TGF-β;    Wnt;    signal transduction;    mesenchymal stem cells;   

DOI  :  

学科分类：分子生物学，细胞生物学和基因

来源: e-Century Publishing Corporation

【 摘 要 】

Bone morphogenetic proteins (BMPs) are members of the TGF-β superfamily and play a critical role in skeletal development, bone formation and stem cell differentiation. Disruptions in BMP signaling result in a variety of skeletal and extraskeletal anomalies. BMP9 is a poorly characterized member of the BMP family and is among the most osteogenic BMPs, promoting osteoblastic differentiation of mesenchymal stem cells (MSCs) both in vitro and in vivo. Recent findings from various in vivo and molecular studies strongly suggest that the mechanisms governing BMP9-mediated osteoinduction differ from other osteogenic BMPs. Many signaling pathways with diverse functions have been found to play a role in BMP9-mediated osteogenesis. Several of these pathways are also critical in the differentiation of other cell lineages, including adipocytes and chondrocytes. While BMP9 is known to be a potent osteogenic factor, it also influences several other pathways including cancer development, angiogenesis and myogenesis. Although BMP9 has been demonstrated as one of the most osteogenic BMPs, relatively little is known about the specific mechanisms responsible for these effects. BMP9 has demonstrated efficacy in promoting spinal fusion and bony non-union repair in animal models, demonstrating great translational promise. This review aims to summarize our current knowledge of BMP9-mediated osteogenesis by presenting recently completed work which may help us to further elucidate these pathways.

【 授权许可】

Unknown