The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function

International Journal of Molecular Sciences

Peihong Su¹  Airong Qian¹  AbdulRouf War¹  Abdul Qadir¹  Yongguang Gao¹  Chong Yin¹  Xiao Lin¹  Ye Tian¹  Xiaoli Ma¹  Suryaji Patil¹  Xue Wang¹ 

[1] Lab for Bone Metabolism, Key Lab for Space Biosciences and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi’an 710072,China;

关键词: foxos;    bone cells;    antioxidant;    osteogenesis;    osteoclastogenesis;    chondrogenesis;    bone diseases;   

DOI  :  10.3390/ijms21030692

来源: DOAJ

【 摘 要 】

Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain. In mammalian species, all the four FoxO members, FoxO1, FoxO3, FoxO4, and FoxO6, are expressed in different organs. In bone, the first three members are extensively expressed and more studied. Bone development, remodeling, and homeostasis are all regulated by multiple cell lineages, including osteoprogenitor cells, chondrocytes, osteoblasts, osteocytes, osteoclast progenitors, osteoclasts, and the intercellular signaling among these bone cells. The disordered FoxOs function in these bone cells contribute to osteoarthritis, osteoporosis, or other bone diseases. Here, we review the current literature of FoxOs for their roles in bone cells, focusing on helping researchers to develop new therapeutic approaches and prevent or treat the related bone diseases.

【 授权许可】

Unknown