Fine-scale Identification of the Most Likely Source of a Human Plague Infection

Emerging Infectious Diseases

关键词: Molecular epidemiology;    plague;    Yersinia pestis;    VNTR;    MLVA;    probabilistic modeling;   

DOI  :  10.3201/eid1510.090188

来源: DOAJ

【 摘 要 】

We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation.

【 授权许可】

Unknown