MicroRNA expression data of pluripotent and somatic cells and identification of cell type-specific MicroRNAs in pigs

Data in Brief

Jong-Nam Oh¹  Gyung Cheol Choe¹  Kwang-Hwan Choi¹  Dongchan Son¹  Seung-Hun Kim¹  Mingyun Lee¹  Jinsol Jeong¹  Dong-Kyung Lee¹  Chang-Kyu Lee¹  Jae Yeon Hwang² 

[1] Department of Agricultural Biotechnology, Animal Biotechnology Major, and Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea;Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT 06510, USA;

关键词: MicroRNA (miRNA);    Pig;    Pluripotency;    Blastocyst;    Embryonic stem cell-like cells;    Embryoid body;   

DOI  :  

来源: DOAJ

【 摘 要 】

Typical models of pluripotency, humans and mice, have been used to analyse the characteristics of pluripotent stem cells. However, these species exhibit molecular differences in many aspects. With similar physiology and genomics as humans, pigs are promising model for the research of pluripotency. The data of porcine pluripotent cells would be helpful in understanding the molecular network of human pluripotency. Pluripotent cells of humans and mice exhibit specific MicroRNA (miRNA) expression patterns to maintain the pluripotent state. Information about miRNA expression in pig pluripotent cells is not sufficient, so we analysed miRNAs in pluripotent (blastocysts and ES-like) and somatic cell samples (PEB and PFF). We screened cell-type specific miRNAs and identified their target genes. Functional annotation of the target genes was also conducted. Our data may facilitate miRNA-based induction and maintenance of the pluripotent state of porcine cells and provide support to fill the gap between the pluripotency networks of humans and mice.

【 授权许可】

Unknown