MicroRNA regulation of liver cancer stem cells

American Journal of Cancer Research

Bisha Ding¹  Guansheng Zhong²  Weimin Fan³  Liang Xu⁴  Yanjia Gao⁵  Jingxing Liu⁶  Weiyang Lou⁷ 

[1] Department of Anesthesiology, International Hospital of Zhejiang University, Shulan (Hangzhou) Hospital, Hangzhou 310003, Zhejiang Province, China;Department of Intensive Care Unit, Changxing Peoples Hospital of Zhejiang, Huzhou 313100, Zhejiang Province, China;Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC 29425, USA;Department of Thyroid and Breast Surgery, Zhejiang Provincial Peoples Hospital, Peoples Hospital of Hangzhou Medical College, Hangzhou 310000, Zhejiang Province, China;Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Hangzhou 310000, China;Key Laboratory of Organ Transplantation, Hangzhou 310003, Zhejiang Province, China;Program of Innovative Cancer Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, College of Medicine, Zhejiang University, Key Laboratory of Organ Transplantation, Hangzhou 310003, Zhejiang Province, China

关键词: MicroRNA (miRNA);    cancer stem cell (CSC);    liver cancer;    EMT;    chemo-resistance;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

MicroRNAs (miRNAs), a class of emerging small non-coding RNAs, serve as vital players in modulating multiple biological processes via the post-transcriptional regulation of gene expression. Dysregulated expression of miRNAs in liver cancer is well documented, and the involvement of miRNAs in liver cancer initiation and progression has also been described. Cancer stem cells (CSCs) are a subset of cells known to be at the root of cancer recurrence and resistance to therapy. In this review, we highlight recent reports indicating that miRNAs participate in the regulation of liver cancer stem cells (LCSCs). The Wnt signaling pathway, TGF-beta signaling pathway, JAK/STAT signaling pathway and epithelial-mesenchymal transition (EMT) are all closely correlated with the miRNA modulation of LCSCs. In addition, several miRNAs have been demonstrated to be involved in the regulation of LCSCs in response to therapy sensitivity. Targeting LCSCs by regulating the expression of these miRNAs represents a potential therapeutic strategy for treating cancer drug resistance, metastasis and recurrence in the near future.

【 授权许可】

CC BY-NC