Predictive and Prognostic Value of Non-Coding RNA in Breast Cancer

Cancers

Alberto D’Angelo¹  Daniele Generali²  Stefano Volinia³  Richard Chahwan⁴  Raheleh Roudi⁵  Dafei Chai⁶  Navid Sobhani⁶  Rachel Morris⁷ 

[1]Department of Biology & Biochemistry, University of Bath, Bath BA27AY, UK

[2]Department of Medical Surgery and Health Sciences, University of Trieste, 34127 Trieste, Italy

[3]Department of Morphology, Embryology and Medical Oncology, Università Degli Studi di Ferrara, 44100 Ferrara, Italy

[4]Institute of Experimental Immunology, University of Zurich, CH-8057 Zurich, Switzerland

[5]Molecular Imaging Program at Stanford, Department of Radiology, Stanford University, Stanford, CA 94305, USA

[6]Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA

[7]Thunder Biotech, 395 Cougar Blvd, Provo, UT 84604, USA

关键词: non-coding RNA;    biomarkers;    breast cancer;    prognostic;    diagnostic;   

DOI  :  10.3390/cancers14122952

来源: DOAJ

【 摘 要 】

For decades since the central dogma, cancer biology research has been focusing on the involvement of genes encoding proteins. It has been not until more recent times that a new molecular class has been discovered, named non-coding RNA (ncRNA), which has been shown to play crucial roles in shaping the activity of cells. An extraordinary number of studies has shown that ncRNAs represent an extensive and prevalent group of RNAs, including both oncogenic or tumor suppressive molecules. Henceforth, various clinical trials involving ncRNAs as extraordinary biomarkers or therapies have started to emerge. In this review, we will focus on the prognostic and diagnostic role of ncRNAs for breast cancer.

【 授权许可】

Unknown