Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene

Nutrients

Melania Melis¹  Mariano Mastinu¹  Roberto Crnjar¹  Giorgia Sollai¹  IoleTomassini Barbarossa¹  Salvatore Magri²  Danilo Paduano²  Fabio Chicco²  Paolo Usai²  Thomas Hummel³ 

[1] Department of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, Italy;Department of Medical Sciences and Public Health, University of Cagliari, Presidio Policlinico of Monserrato, 09042 Cagliari, Italy;Smell and Taste Clinic, Department of Otorhinolaryngology, TU Dresden, 01067 Dresden, Germany;

关键词: smell;    olfactory dysfunction;    Crohn’s disease (CD) and ulcerative colitis (UC);    odorant binding proteins (OBPs) gene;    BMI;    nutrition;   

DOI  :  10.3390/nu13020703

来源: DOAJ

【 摘 要 】

Smell strongly contributes to food choice and intake, influencing energy balance and body weight; its reduction or loss has been related to malnutrition problems. Some patients with inflammatory bowel disease (IBD), mainly Crohn’s disease (CD) and ulcerative colitis (UC), are underweight, while others are overweight. Some studies suggest that changes in eating habits could be linked to specific disorders of the olfactory functions. We assessed the olfactory performance in 199 subjects (healthy control (HC) n = 99, IBD n = 100), based on the olfactory Threshold, Discrimination and Identification score (TDI score), measured with the “Sniffin’ Sticks” test. Subjects were genotyped for the rs2590498 polymorphism of the OBPIIa gene. IBD patients showed both a slightly, but significantly, lower olfactory function and a higher BMI compared to HC subjects. Threshold (in both population) and Discrimination (in IBD patients) olfactory score were affected by the OBPIIa genotype. BMI was influenced by both health status and OBPIIa genotype. A lower olfactory function may delay the satiety sensation and thus increase meal duration and body weight in IBD patients. However, the AA genotype of the OBPIIa seems to “protect” IBD patients from more severe olfactory dysfunction.

【 授权许可】

Unknown