AMPK: An Epigenetic Landscape Modulator

International Journal of Molecular Sciences

Indah Sari¹  Tiffany Bryant¹  Geraldine Rosete¹  Brendan Gongol²  Traci Marin² 

[1] Department of Cardiopulmonary Sciences, School of Allied Health Professions, Loma Linda University, Loma Linda, CA 92350, USA;Department of Medicine, University of California, San Diego, CA 92093, USA;

关键词: AMPK;    epigenetics;    chromatin remodeling;    histone modification;    DNA methylation;   

DOI  :  10.3390/ijms19103238

来源: DOAJ

【 摘 要 】

Activated by AMP-dependent and -independent mechanisms, AMP-activated protein kinase (AMPK) plays a central role in the regulation of cellular bioenergetics and cellular survival. AMPK regulates a diverse set of signaling networks that converge to epigenetically mediate transcriptional events. Reversible histone and DNA modifications, such as acetylation and methylation, result in structural chromatin alterations that influence transcriptional machinery access to genomic regulatory elements. The orchestration of these epigenetic events differentiates physiological from pathophysiological phenotypes. AMPK phosphorylation of histones, DNA methyltransferases and histone post-translational modifiers establish AMPK as a key player in epigenetic regulation. This review focuses on the role of AMPK as a mediator of cellular survival through its regulation of chromatin remodeling and the implications this has for health and disease.

【 授权许可】

Unknown