Epigenetic Regulation in Sepsis, Role in Pathophysiology and Therapeutic Perspective

Frontiers in Medicine

article

Renata Brito Falcão-Holanda¹  Milena Karina Colo Brunialti¹  Miriam Galvonas Jasiulionis²  Reinaldo Salomão¹ 

[1] Division of Infectious Diseases, Universidade Federal de São Paulo;Department of Pharmacology, Universidade Federal de São Paulo

关键词: sepsis;    epigenetics;    chromatin remodeling;    DNA methylation;    histone modification;   

DOI  :  10.3389/fmed.2021.685333

学科分类：社会科学、人文和艺术（综合）

来源: Frontiers

【 摘 要 】

Sepsis is characterized by an initial hyperinflammatory response, with intense cell activation and cytokine storm. In parallel, a prolonged compensatory anti-inflammatory response, known as immunological tolerance, can lead to immunosuppression. Clinically, this condition is associated with multiple organ failure, resulting in the patient's death. The mechanisms underlying the pathophysiology of sepsis are not yet fully understood, but evidence is strong showing that epigenetic changes, including DNA methylation and post-translational modifications of histones, modulate the inflammatory response of sepsis. During the onset of infection, host cells undergo epigenetic changes that favor pathogen survival. Besides, epigenetic changes in essential genes also orchestrate the patient's inflammatory response. In this review, we gathered studies on sepsis and epigenetics to show the central role of epigenetic mechanisms in various aspects of the pathogenesis of sepsis and the potential of epigenetic interventions for its treatment.

【 授权许可】

CC BY