Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

International Journal of Molecular Sciences

关键词: osteoprogenitor;    bone marrow stromal cell;    mesenchymal stem cell;    transplantation;    tissue reconstruction;   

DOI  :  10.3390/ijms130810229

来源: DOAJ

【 摘 要 】

We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.

【 授权许可】

Unknown