Bone Marrow-Derived HipOP Cell Population Is Markedly Enriched in Osteoprogenitors

International Journal of Molecular Sciences

Shousaku Itoh¹  Kenta Matsushita¹  Shun Ikeda¹  Yumiko Yamamoto¹  Yukako Yamauchi¹  Seisuke Yoshioka¹  Reiko Yamamoto¹  Shigeyuki Ebisu¹  Mikako Hayashi¹ 

[1] Department of Restorative Dentistry and Endodontology, Osaka University Graduate School of Dentistry, 1-8, Yamada-oka Suita, Osaka 565-0871, Japan; E-Mails:

关键词: osteoprogenitor;    bone marrow stromal cell;    mesenchymal stem cell;    transplantation;    tissue reconstruction;   

DOI  :  10.3390/ijms130810229

来源: mdpi

【 摘 要 】

We recently succeeded in purifying a novel multipotential progenitor or stem cell population from bone marrow stromal cells (BMSCs). This population exhibited a very high frequency of colony forming units-osteoblast (CFU-O; 100 times higher than in BMSCs) and high expression levels of osteoblast differentiation markers. Furthermore, large masses of mineralized tissue were observed in in vivo transplants with this new population, designated highly purified osteoprogenitors (HipOPs). We now report the detailed presence and localization of HipOPs and recipient cells in transplants, and demonstrate that there is a strong relationship between the mineralized tissue volume formed and the transplanted number of HipOPs.

【 授权许可】

CC BY   
© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.