Saccharomyces cerevisiae–based probiotic as novel anti-microbial agent for therapy of bacterial vaginosis

Virulence

Amélie Cayzeele Decherf¹  Fanny Pélerin¹  Nathalie Ballet²  Samuele Sabbatini³  Stefano Perito³  Anna Vecchiarelli³  Paolo Mosci⁴  Paolo Scarpelli⁴  Claudia Monari⁴ 

[1] Lesaffre Human Care, Lesaffre Group;Lesaffre International, Lesaffre Group;Medical Microbiology Section, University of Perugia;University of Perugia;

关键词: probiotic;    G. vaginalis;    S. cerevisiae;    bacterial vaginosis;    sialidase;    exfoliation;    adherence;    displacement;   

DOI  :  10.1080/21505594.2018.1464362

来源: DOAJ

【 摘 要 】

In this study, we demonstrate, for the first time, that Saccharomyces cerevisiae-based probiotic shows an inhibitory effect on Gardnerella vaginalis infection. This effect is likely due to several actions: direct interference with adherence to vaginal tissues, inhibition of sialidase activity, reduction of vaginal epithelial exfoliation. Gardnerella vaginalis does not induce vaginal inflammation and no inflammatory cytokines were, indeed, produced, by the mouse vagina, neither by Gardnerella vaginalis and by the probiotic. Collectively, our data incite to further investigations on Saccharomyces cerevisiae probiotic as a potential prophylactic or therapeutic agent in the vaginosis caused by Gardnerella vaginalis.

【 授权许可】

Unknown