Cardiac phenotype in mouse models of systemic autoimmunity

Disease Models & Mechanisms

Lok Man Wong¹  Amalia Sintou¹  Susanne Sattler¹  Chandan Sanghera¹  Mona Panahi¹  Muneer Hasham² 

[1] National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK;The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA;

关键词: Heart disease;    Heart failure;    Mouse model;    Myocarditis;    SLE;    Systemic autoimmunity;   

DOI  :  10.1242/dmm.036947

来源: DOAJ

【 摘 要 】

Patients suffering from systemic autoimmune diseases are at significant risk of cardiovascular complications. This can be due to systemically increased levels of inflammation leading to accelerated atherosclerosis, or due to direct damage to the tissues and cells of the heart. Cardiac complications include an increased risk of myocardial infarction, myocarditis and dilated cardiomyopathy, valve disease, endothelial dysfunction, excessive fibrosis, and bona fide autoimmune-mediated tissue damage by autoantibodies or auto-reactive cells. There is, however, still a considerable need to better understand how to diagnose and treat cardiac complications in autoimmune patients. A range of inducible and spontaneous mouse models of systemic autoimmune diseases is available for mechanistic and therapeutic studies. For this Review, we systematically collated information on the cardiac phenotype in the most common inducible, spontaneous and engineered mouse models of systemic lupus erythematosus, rheumatoid arthritis and systemic sclerosis. We also highlight selected lesser-known models of interest to provide researchers with a decision framework to choose the most suitable model for their study of heart involvement in systemic autoimmunity.

【 授权许可】

Unknown