Effects of a Short-Term Resistance-Training Program on Heart Rate Variability in Children With Cystic Fibrosis—A Randomized Controlled Trial

Frontiers in Physiology

Maria Fernández-del-Valle¹  Ignacio Diez-Vega²  Eneko Larumbe-Zabala²  Fernando Cobo-Vicente²  Álvaro Fernández-Luna²  Agustín Jesús Estévez-González²  Margarita Pérez-Ruiz²  Márcio Vinícius Fagundes Donadio³  Tamara Iturriaga Ramirez³  José Ramón Villa Asensi⁴  Verónica Sanz-Santiago⁴ 

[1] Department of Applied Health, Southern Illinois University (SIUE), Edwardsville, IL, United States;Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain;Laboratory of Pediatric Physical Activity, Centro Infant, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil;Pulmonology Unit, Hospital Universitario Niño Jesús de Madrid, Madrid, Spain;

关键词: heart rate variability;    exercise;    resistance;    autonomic function;    pediatrics;    cystic fibrosis;   

DOI  :  10.3389/fphys.2021.652029

来源: DOAJ

【 摘 要 】

Background: Cystic fibrosis (CF) affects the autonomic nervous system (ANS) and exercise in healthy children modulates the interaction between sympathetic and parasympathetic activity. This study aimed to evaluate the effects of a short-term resistance exercise program on heart rate variability (HRV) in children and adolescents with CF.Methods: A randomized controlled trial was carried out in children diagnosed with CF aged 6–18 years. Individuals were divided into two groups: control (CON) and resistance-training (EX). Individuals in the EX group completed an individualized guided resistance program (5-RM—60–80%) for 8 weeks (3 sessions of 60 min/week). Upper and lower limbs exercises (seated bench press, seated lateral row, and leg press) were used. HRV was measured using a Suunto watch with subjects in lying position.Results: Nineteen subjects (13 boys) were included (CON = 11; and EX = 8). Mean age was 12.2 ± 3.3, FEV1 (forced expiratory volume in the first second) z-score was 1.72 ± 1.54 and peak oxygen consumption (VO2peak) 42.7 ± 7.4 mL.Kg–1.min–1. Exercise induced significant changes in the frequency-domain variables, including a decrease in LF power (p = 0.001, d = 0.98) and LF/HF ratio (p = 0.020, d = 0.92), and an increase in HF power (p = 0.001, d = −0.97), compared to the CON group. No significant changes were found for time-domain variables, although increases with a moderate effect size were seen for SDNN (p = 0.152, d = −0.41) and RMSSD (p = 0.059, d = −0.49) compared to the CON group.Conclusion: A short-term resistance exercise-training program was able to modulate HRV in children and adolescents with CF presenting mild to moderate lung function impairment and good physical condition.Clinical Trial Registration:www.ClinicalTrials.gov, identifier NCT04293926.

【 授权许可】

Unknown