Association between adiponectin-to-leptin ratio and heart rate variability in new-onset paroxysmal atrial fibrillation: A retrospective cohort study

Annals of noninvasive electrocardiology: the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc

article

Tongjian Zhu MD, PhD¹  Mingxian Chen MD, PhD³  Meng Wang MD¹  Zhuo Wang MD, PhD¹  Songyun Wang MD, PhD¹  He Hu MD²  Kezhong Ma MD²  Hong Jiang MD, PhD¹ 

[1] Hubei Key Laboratory of Cardiology, Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute, Wuhan University;Department of Cardiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science;Department of Cardiology, The Second Xiangya Hospital, Central South University

关键词: adiponectin;    autonomic function;    heart rate variability;    leptin;    paroxysmal atrial fibrillation;   

DOI  :  10.1111/anec.12896

来源: Wiley

【 摘 要 】

Background The adiponectin-to-leptin (A/L) ratio has been identified as a potential surrogate biomarker for metabolic disorders. However, it remains unknown whether the serum A/L ratio is associated with heart rate variability in paroxysmal atrial fibrillation (AF). Methods For this retrospective study, we included consecutive patients who underwent 24-h long-range electrocardiogram examination in our center for paroxysmal AF. The results of echocardiography, heart rate variability tests, and blood tests were also retrieved. Multivariate line regression analysis was performed to evaluate identify factors independently associated with heart rate variability. Results Among the 85 included patients with paroxysmal AF, the median A/L ratio was 1.71. Univariate analysis indicated that patients with a low A/L ratio (<1.71, n  = 42) had a lower high-frequency (HF) power and a higher hs-CRP level, low-frequency (LF) power, and LF/HF ratio than those with a high A/L ratio (≥1.71, n  = 43). Multivariate linear regression analysis showed that the serum leptin concentration was independently and positively associated with LF (β = 0.175, p  = .028), while the serum adiponectin concentration was independently and positively associated with HF (β = 0.321, p  = .001). Moreover, the A/L ratio was independently and negatively associated with the LF/HF ratio (β = −0.276, p  = .007). Conclusions The A/L ratio was independently and negatively associated with the LF/HF ratio in patients with new-onset paroxysmal AF.

【 授权许可】

Unknown