EpCAM Expression in Lymph Node and Bone Metastases of Prostate Carcinoma: A Pilot Study

International Journal of Molecular Sciences

Geert J. L. H. van Leenders¹  Stefano Rosati²  Igle J. de Jong³  Hilde D. Hoving³  Anna K. Campos⁴ 

[1] Department of Pathology, Josephine Nefkens Institute, Erasmus MC, P.O. Box 2040, Rotterdam 3000 CA, The Netherlands;Department of Pathology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen 9700 RB, The Netherlands;Department of Urology, University Medical Center Groningen, University of Groningen, P.O. Box 30.001, Groningen 9700 RB, The Netherlands;Laboratory of Neuroimmunology, National Institute of Neurology and Neurosurgery “Manuel Velasco Suárez”, Avenida Insurgentes Sur 3877, La Fama, Tlalpan, 14269 Mexico City, Mexico;

关键词: molecular imaging;    imaging target;    prostate carcinoma;    metastases;    epithelial cell adhesion molecule (EpCAM);    immunohistochemistry;   

DOI  :  10.3390/ijms17101650

来源: DOAJ

【 摘 要 】

There is an urgent need for new imaging modalities in prostate carcinoma staging. A non-invasive modality that can assess lymph node and bone metastases simultaneously is preferred. Epithelial cell adhesion molecule (EpCAM) is a membranous protein of interest as an imaging target since it is overexpressed in prostatic carcinoma compared with benign prostate epithelium and compared with stroma. However, EpCAM expression in lymph node metastases is sparsely available in the literature and EpCAM expression in bone metastases is yet unknown. The current study evaluates the expression of EpCAM in prostate carcinoma lymph nodes, in matched normal lymph nodes, in prostate carcinoma bone metastases, and in normal bone by immunohistochemistry. EpCAM was expressed in 100% of lymph node metastases (21 out of 21), in 0% of normal lymph nodes (0 out of 21), in 95% of bone metastases (19 out of 20), and in 0% of normal bone (0 out of 14). Based on these results, EpCAM may be a feasible imaging target in prostate carcinoma lymph node and bone metastases. Prospective clinical trials are needed to confirm current results. Preoperative visualization of prostate carcinoma metastases will improve disease staging and will prevent unnecessary invasive surgery.

【 授权许可】

Unknown