RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis

Cancers

Mark Sutherland¹  Andrew Gordon¹  Steven D. Shnyder¹  Laurence H. Patterson¹ 

[1] Institute of Cancer Therapeutics, University of Bradford, Bradford, BD7 1RL, UK;

关键词: integrin;    RGD;    prostate carcinoma;    bone metastasis;   

DOI  :  10.3390/cancers4041106

来源: mdpi

【 摘 要 】

Prostate cancer is the third leading cause of male cancer deaths in the developed world. The current lack of highly specific detection methods and efficient therapeutic agents for advanced disease have been identified as problems requiring further research. The integrins play a vital role in the cross-talk between the cell and extracellular matrix, enhancing the growth, migration, invasion and metastasis of cancer cells. Progression and metastasis of prostate adenocarcinoma is strongly associated with changes in integrin expression, notably abnormal expression and activation of the β₃ integrins in tumour cells, which promotes haematogenous spread and tumour growth in bone. As such, influencing integrin cell expression and function using targeted therapeutics represents a potential treatment for bone metastasis, the most common and debilitating complication of advanced prostate cancer. In this review, we highlight the multiple ways in which RGD-binding integrins contribute to prostate cancer progression and metastasis, and identify the rationale for development of multi-integrin antagonists targeting the RGD-binding subfamily as molecularly targeted agents for its treatment.

【 授权许可】

CC BY   
© 2012 by the authors; licensee MDPI, Basel, Switzerland.