Baccaurea angulata fruit juice reduces atherosclerotic lesions in diet-induced Hypercholesterolemic rabbits

Lipids in Health and Disease

Afzan Mat Yusof¹  Muhammad Ibrahim²  Maryam Abimbola Mikail²  Idris Adewale Ahmed²  Afeez Adekunle Ishola³  Samsul Draman³  Muhammad Lokman Md Isa⁴ 

[1]Department of Biomedical Science, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia

[2]Department of Nutrition Sciences, Kulliyyah of Allied Health Sciences, International Islamic University Malaysia

[3]Kulliyyah of Medicine, International Islamic University Malaysia

[4]Kulliyyah of Nursing, International Islamic University Malaysia

关键词: Atherosclerosis;    Hypercholesterolemia;    Intima thickness;    Lesion;    Lipid profile;   

DOI  :  10.1186/s12944-017-0526-2

来源: DOAJ

【 摘 要 】

Abstract Background Atherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued. Methods Thirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups. Four groups were fed 1% cholesterol diet and 0, 0.5, 1.0, and 1.5 mL of BA fruit juice per kg of rabbit daily (atherogenic groups), while the other three groups were fed commercial rabbit pellet and 0, 0.5, and 1.0 mL of juice per kg of rabbit daily (normocholesterolemic groups) for 90 days. The thoracic and abdominal aorta between the heart origin and bifurcation into iliac arteries of all the rabbits were carefully removed and analyzed accordingly. Results The supplementation of the high-cholesterol diet of hypercholesterolemic rabbits with only 0.5 mL BA/kg rabbit per day significantly (p < 0.001) improved aortic lipid profile, attenuated aortic fatty streak development and reduced intima thickening. Higher BA doses used (1.0 and 1.5 mL/kg rabbit per day) also significantly (p < 0.001) decreased further the development of aortic fatty streaks, reduced the thickening of the tunica intima layer and preserved endothelial healing following arterial injury. Conclusion Therefore, BA fruit is a potential novel functional food with effective anti-inflammatory, anti-atherogenic and hypocholesterolemic activities.

【 授权许可】

Unknown