Phospholipase D and phosphatidic acid in the biogenesis and cargo loading of extracellular vesicles

Journal of Lipid Research

Antonio Luis Egea-Jimenez¹  Pascale Zimmermann¹ 

[1] Centre de Recherche en Cancérologie de Marseille (CRCM), Equipe labellisée LIGUE 2018, Aix-Marseille Université, Marseille F-13284, France and Inserm U1068, Institut Paoli-Calmettes, and CNRS UMR7258, Marseille F-13009, France;

关键词: cell signaling;    endocytosis;    membranes;    phospholipases;    phospholipids;    exosomes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Extracellular vesicles released by viable cells (exosomes and microvesicles) have emerged as important organelles supporting cell-cell communication. Because of their potential therapeutic significance, important efforts are being made toward characterizing the contents of these vesicles and the mechanisms that govern their biogenesis. It has been recently demonstrated that the lipid modifying enzyme, phospholipase D (PLD)2, is involved in exosome production and acts downstream of the small GTPase, ARF6. This review aims to recapitulate our current knowledge of the role of PLD2 and its product, phosphatidic acid, in the biogenesis of exosomes and to propose hypotheses for further investigation of a possible central role of these molecules in the biology of these organelles.

【 授权许可】

Unknown