Synthesis of (E)-2-Styrylchromones and Flavones byBase-Catalyzed Cyclodehydration of the Appropriateβ-Diketones Using Water as Solvent

Molecules

Vera L. M. Silva¹  Joana Pinto¹  Artur M. S. Silva¹  Ana M. G. Silva² 

[1] Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal;UCIBIO/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal;

关键词: (E)-2-styrylchromones;    flavones;    cyclodehydration reactions;    microwave heating;    reactions in water;   

DOI  :  10.3390/molecules200611418

来源: DOAJ

【 摘 要 】

A low cost, safe, clean and environmentally benign base-catalyzed cyclodehydration of appropriate β-diketones affording (E)-2-styrylchromones and flavones in good yields is disclosed. Water was used as solvent and the reactions were heated using classical and microwave heating methods, under open and closed vessel conditions. β-Diketones having electron-donating and withdrawing substituents were used to evaluate the reaction scope. The reaction products were isolated in high purity by simple filtration and recrystallization from ethanol, when using 800 mg of the starting diketone under classical refluxheating conditions.

【 授权许可】

Unknown