Synthesis of (E)-2-Styrylchromones and Flavones by Base-Catalyzed Cyclodehydration of the Appropriate β-Diketones Using Water as Solvent

Molecules

Joana Pinto¹  Vera L. M. Silva¹  Ana M. G. Silva²  Artur M. S. Silva¹ 

[1] Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal; E-Mail:;UCIBIO/REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, 4169-007 Porto, Portugal; E-Mail:

关键词: (E)-2-styrylchromones;    flavones;    cyclodehydration reactions;    microwave heating;    reactions in water;   

DOI  :  10.3390/molecules200611418

来源: mdpi

【 摘 要 】

A low cost, safe, clean and environmentally benign base-catalyzed cyclodehydration of appropriate β-diketones affording (E)-2-styrylchromones and flavones in good yields is disclosed. Water was used as solvent and the reactions were heated using classical and microwave heating methods, under open and closed vessel conditions. β-Diketones having electron-donating and withdrawing substituents were used to evaluate the reaction scope. The reaction products were isolated in high purity by simple filtration and recrystallization from ethanol, when using 800 mg of the starting diketone under classical reflux heating conditions.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.