期刊论文详细信息
Molecules | |
A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process | |
Yongxi Liang1  Xun Sun1  Mei-Lin Tang1  Zhipeng Huo1  Chenchen Zhang1  | |
[1] Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China; | |
关键词: base; one-pot; coupling; cyclization; metal-free; | |
DOI : 10.3390/molecules25051138 | |
来源: DOAJ |
【 摘 要 】
An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.
【 授权许可】
Unknown