A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process

Molecules

Yongxi Liang¹  Xun Sun¹  Mei-Lin Tang¹  Zhipeng Huo¹  Chenchen Zhang¹ 

[1] Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China;

关键词: base;    one-pot;    coupling;    cyclization;    metal-free;   

DOI  :  10.3390/molecules25051138

来源: DOAJ

【 摘 要 】

An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.

【 授权许可】

Unknown