In vitro pharmacoregulation of CC chemokine ligand 5 and its receptor CCR5 in diffuse lung diseases

Mediators of Inflammation

Agata Gibejova¹  Martin Petrek¹  Veronika Sekerova¹  Daniela Subrtova¹  Frantisek Mrazek¹  Vitezslav Kolek²  Roland M. du Bois³ 

[1] Department of Immunology, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech Republic;Department of Respiratory Medicine, Palacky University, I. P. Pavlova 6, Olomouc CZ-775 20, Czech Republic;Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK;

关键词: Dexamethasone;    Cyclosporin A;    Pentoxifylline;    Sarcoidosis;    RANTES;    Glucocorticoids;    Bronchoalveolar cells.;   

DOI  :  10.1080/09629350310001599657

来源: DOAJ

【 摘 要 】

Background: CC chemokine ligand (CCL)5 and its receptor CCR5 contribute to leukocyte migration into lungs of patients with diffuse lung diseases (DLD). Pharmacological regulation of CCL5 and CCR5 expression was therefore explored in bronchoalveolar cells obtained from patients with DLD.

【 授权许可】

Unknown