Overview of Albumin and Its Purification Methods

Advanced Pharmaceutical Bulletin

Ali Mota¹  Ramin Raoufinia²  Neda Keyhanvar²  Fatemeh Safari²  Sara Shamekhi²  Jalal Abdolalizadeh³ 

[1] Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.;Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ;Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.;

关键词: Human serum albumin;    Purification;    Chromatography;    Immunoaffinity;   

DOI  :  10.15171/apb.2016.063

来源: DOAJ

【 摘 要 】

As the most frequent plasma protein, albumin constitutes more than 50% of the serum proteins in healthy individuals. It has a key role in oncotic pressure maintenance and it is known as a versatile protein carrier for transportation of various endogenous and exogenous ligands. Reduced amounts of albumin in the body will lead to different kinds of diseases such as hypovolemia and hypoproteinemia. It also has various indications in shocks, burns, cardiopulmonary bypass, acute liver failure and etc. Further applications in research consist of cell culture supplement, drug delivery carrier and protein/drug stabilizer. So, the demand for albumin increased annually worldwide. Due to different applications of albumin, many efforts have been accomplished to achieve albumin during a long period of time. In this review, an overview of serum albumin and different purification methods are summarized.

【 授权许可】

Unknown