Risk Groups of Developing Active Tuberculosis in Liver Transplant Recipients in a Tuberculosis Endemic Area: Risk Stratification by Chest Image and Interferon Gamma Release Assay

International Journal of Infectious Diseases

Suhyun Oh¹  Jae-Won Joh²  Jong Man Kim²  Gyu-Seong Choi²  Si-Ho Kim³  Eliel Nham⁴  Jae-Hoon Ko⁴  Doo Ryeon Chung⁴  Cheol-In Kang⁴  Sun Young Cho⁴  Kyungmin Huh⁴  Kyong Ran Peck⁴ 

[1] Department of Internal Medicine, Seogwipo Medical Center, Jeju, Korea;Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University, Changwon, Korea;Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea;

关键词: Tuberculosis;    Latent tuberculosis infection;    Liver transplantation;    Interferon-gamma release assay;    Chest image;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objectives: We implemented a stratified risk analysis to predict the development of active tuberculosis (TB) in liver transplantation (LT) recipients based on IGRA and chest images in a TB-endemic area. Methods: In this retrospective cohort study, LT recipients who tested for IGRA between May 2008 and December 2017 were included. Chest images compatible with old TB lesions were considered as positive images. LT recipients were divided into six groups: LT recipients with history of treated TB, image (+)/IGRA (+), image (+)/IGRA (-), image (-)/IGRA (+), image (-)/IGRA (-) and LTBI treated. The Cox regression model was used to analyze risk groups. Results: Among the 717 eligible LT recipients included in this study, 21 patients developed active TB. Incidence rates of TB were 2,261, 724, and 119 cases/100,000 person-years in the 1st, 2nd, and ≥ 3rd year after transplantation, respectively. History of treated TB (HR 18.92; 95% CI 4.10–87.25) and image (+)/IGRA (+) (HR 10.86; 95% CI 2.75–42.89) were independent risk factors for developing active TB. IGRA (+) with a negative image was not a risk factor. Conclusions: Our findings suggested that both IGRA and chest images should be considered to identify risk groups for LTBI treatment.

【 授权许可】

Unknown