The use of induced pluripotent stem cells in domestic animals: a narrative review

BMC Veterinary Research

Rachel A. Scarfone¹  Keith A. Russell¹  Thomas G. Koch¹  Samantha M. Pena¹  Dean H. Betts² 

[1] Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph;Department of Physiology and Pharmacology, The University of Western Ontario;

关键词: Induced pluripotent stem cells;    Domestic species;    Veterinary medicine;    Production;    Characterization;    Disease modelling;   

DOI  :  10.1186/s12917-020-02696-7

来源: DOAJ

【 摘 要 】

Abstract Induced pluripotent stem cells (iPSCs) are undifferentiated stem cells characterized by the ability to differentiate into any cell type in the body. iPSCs are a relatively new and rapidly developing technology in many fields of biology, including developmental anatomy and physiology, pathology, and toxicology. These cells have great potential in research as they are self-renewing and pluripotent with minimal ethical concerns. Protocols for their production have been developed for many domestic animal species, which have since been used to further our knowledge in the progression and treatment of diseases. This research is valuable both for veterinary medicine as well as for the prospect of translation to human medicine. Safety, cost, and feasibility are potential barriers for this technology that must be considered before widespread clinical adoption. This review will analyze the literature pertaining to iPSCs derived from various domestic species with a focus on iPSC production and characterization, applications for tissue and disease research, and applications for disease treatment.

【 授权许可】

Unknown