Liver organoids in domestic animals: an expected promise for metabolic studies

Veterinary Research

Bertrand Pain¹  Camille Baquerre¹  Guillaume Montillet¹ 

[1] Univ Lyon, Université Lyon 1, INSERM, INRAE, Stem Cell and Brain Research Institute, U1208, USC1361, 69500, Bron, France;

关键词: Liver organoids;    Pluripotent stem cells;    Mammals;    Birds;    Domestic species;   

DOI  :  10.1186/s13567-021-00916-y

来源: Springer

【 摘 要 】

The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol, drugs, antibiotics, etc.). The development of a relevant model that reproduces some of the functions of this tissue has become a challenge, in particular for human medicine. Thus, in recent years, most studies aimed at producing hepatocytes in vitro with the goal of developing hepatic 3D structures have been carried out in the human model. However, the tools and protocols developed using this unique model can also be considered to address physiological questions specific to this tissue in other species, such as the pig, chicken, and duck. Different strategies are presently being considered to carry out in vitro studies of the hepatic metabolism of these agronomic species.

【 授权许可】

CC BY