Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates from hospitals in Myanmar

Journal of Global Antimicrobial Resistance

Htay Htay Tin¹  Teruo Kirikae²  Mari Tohya²  Tatsuya Tada²  Kyoko Kuwahara-Arai²  Hiroki Uchida²  Tomomi Hishinuma²  Shin Watanabe³  Khin Nyein Zan⁴  San Mya⁴ 

[1] Corresponding author at: Department of Microbiology, Juntendo University Graduate School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.;Department of Microbiology, Juntendo University Graduate School of Medicine, Tokyo, Japan;Department of Microbiome Research, Juntendo University Graduate School of Medicine, Tokyo, Japan;National Health Laboratory, Yangon, Myanmar;

关键词: Multidrug-resistant Acinetobacter baumannii;    16S rRNA methylase;    molecular epidemiology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: The aim of this study was to clarify the genetic and epidemiological properties of multidrug-resistant Acinetobacter baumannii in medical settings in Myanmar. Methods: A total of 45 A. baumannii clinical isolates were obtained in medical settings in Myanmar. The whole genomes were sequenced by a next generation sequencer, and the phylogenetic tree was constructed from single nucleotide polymorphism concatemers. Multilocus sequence types were deduced and drug resistance genes were identified. Results: Thirty-eight MDR Acinetobacter baumannii isolates were obtained from seven hospitals in Myanmar. The majority of MDR A. baumannii isolates belonged to ST2. Of the 38 isolates, 5 harbored blaNDM-1, and 28 did armA or armA2 Conclusions: A. baumannii ST2 producing 16S rRNA methylase ArmA has been spreading in medical settings in Myanmar.

【 授权许可】

Unknown