Endoplasmic Reticulum Stress in Metabolic Disorders

Cells

Rose Ghemrawi¹  Carole Arnold²  Shyue-Fang Battaglia-Hsu² 

[1] College of Pharmacy, Al Ain University of Science and Technology, 112612 Abu Dhabi, UAE;Nutrition Génétique et Exposition aux Risques Environnementaux, INSERM Unité 1256, Université de Lorraine, 54000 Vandoeuvre les Nancy, France;

关键词: endoplasmic reticulum stress;    metabolic disorders;    unfolded protein response;    inflammation;    lipotoxicity;    glucotoxicity;    therapy;   

DOI  :  10.3390/cells7060063

来源: DOAJ

【 摘 要 】

Metabolic disorders have become among the most serious threats to human health, leading to severe chronic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease, as well as cardiovascular diseases. Interestingly, despite the fact that each of these diseases has different physiological and clinical symptoms, they appear to share certain pathological traits such as intracellular stress and inflammation induced by metabolic disturbance stemmed from over nutrition frequently aggravated by a modern, sedentary life style. These modern ways of living inundate cells and organs with saturating levels of sugar and fat, leading to glycotoxicity and lipotoxicity that induce intracellular stress signaling ranging from oxidative to ER stress response to cope with the metabolic insults (Mukherjee, et al., 2015). In this review, we discuss the roles played by cellular stress and its responses in shaping metabolic disorders. We have summarized here current mechanistic insights explaining the pathogenesis of these disorders. These are followed by a discussion of the latest therapies targeting the stress response pathways.

【 授权许可】

Unknown