Endoplasmic Reticulum Stress and miRNA Impairment in Aging and Age-Related Diseases

Frontiers in Aging

卷:2

Tugce Demirel-Yalciner¹  Nesrin Kartal Ozer¹  Erdi Sozen² 

[1] Department of Biochemistry, Faculty of Medicine, Marmara University, Maltepe, Turkey;

[2] Genetic and Metabolic Diseases Research and Investigation Center (GEMHAM), Marmara University, Maltepe, Turkey;

关键词: aging;    endoplasmic reticulum stress;    microRNA;    metabolic disorders;    neurodegenerative diseases;    cardiovascular diseases;   

DOI  :  10.3389/fragi.2021.790702

来源: DOAJ

【 摘 要 】

Aging is a physiological process defined by decreased cellular and tissue functions. Reduced capacity of protein degradation is one of the important hallmarks of aging that may lead to misfolded protein accumulation and progressive loss of function in organ systems. Recognition of unfolded/misfolded protein aggregates via endoplasmic reticulum (ER) stress sensors activates an adaptive mechanism, the unfolded protein response (UPR). The initial step of UPR is defined by chaperone enhancement, ribosomal translation suppression, and misfolded protein degradation, while prolonged ER stress triggers apoptosis. MicroRNAs (miRNAs) are non-coding RNAs affecting various signaling pathways through degradation or translational inhibition of targeted mRNAs. Therefore, UPR and miRNA impairment in aging and age-related diseases is implicated in various studies. This review will highlight the recent insights in ER stress–miRNAs alterations during aging and age-related diseases, including metabolic, cardiovascular, and neurodegenerative diseases and several cancers.

【 授权许可】

Unknown