Mechanisms of PhotoBioModulation (PBM) focused on oral mucositis prevention and treatment: a scoping review

BMC Oral Health

René-Jean Bensadoun¹  Safa Louati²  Nicolas Magné²  Jean-Baptiste Guy²  Wafa Bouleftour²  Elodie Courtois³  Claire Rodriguez-Lafrasse⁴ 

[1] Centre de Haute Énergie (CHE);Département de Radiothérapie, Institut de Cancérologie de La Loire - Lucien Neuwirth;NeoMedLight;UMR CNRS 5822 /IN2P3, IPNL, PRISME, Laboratoire de Radiobiologie Cellulaire Et Moléculaire, Faculté de Médecine Lyon-Sud, Université Lyon 1;

关键词: Oral mucositis;    Phototherapy;    Photobiomodulation;    Prevention;   

DOI  :  10.1186/s12903-021-01574-4

来源: DOAJ

【 摘 要 】

Abstract Background Oral mucositis (OM) is a severe complication cancer patients undergo when treated with chemoradiotherapy. Photobiomodulation (PBM) therapy also known as low-level laser therapy has been increasingly used for the treatment of such oral toxicity. The aim of this review is to discuss the mechanisms of photobiomodulation (PBM) regarding OM prevention and treatment, and more precisely to focus on the effect of PBM on tumor and healthy cells. Methods MEDLINE/PubMed, and google scholar were searched electronically. Selected studies were focusing on PBM effects on tumor and healthy cells. Results PBM interactions with the tissue and additional mechanism in OM therapy were detailed in this review. Moreover, this review highlighted a controversy about the carcinogenic effect of PBM. Indeed, Many studies reported that PBM could enhance malignant cell proliferation; suggesting that PBM would have no protective effect. In addition to acting on cancer cells, PBM may damage healthy cells. Conclusion More prospective studies are needed to assess the effect of PBM on cancer cells in order to improve its use for OM prevention and treatment.

【 授权许可】

Unknown