Structure and catalytic mechanism of human protein tyrosine phosphatome

BMB Reports

关键词: Classical PTP;    Crystal structure;    Dual specificity PTP;    Eyes absent;    Protein tyrosine phosphatase (PTP);   

DOI  :  

来源: DOAJ

【 摘 要 】

Together with protein tyrosine kinases (PTKs), protein tyrosinephosphatases (PTPs) serve as hallmarks in cellular signaltransduction by controlling the reversible phosphorylation oftheir substrates. The human genome is estimated to encodemore than 100 PTPs, which can be divided into elevensub-groups according to their structural and functionalcharacteristics. All the crystal structures of catalytic domains ofsub-groups have been elucidated, enabling us to understandtheir precise catalytic mechanism and to compare theirstructures across all sub-groups. In this review, I describe thestructure and mechanism of catalytic domains of PTPs in thestructural context.

【 授权许可】

Unknown