Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

BMC Medical Research Methodology

Ewald Bronkhorst¹  Nicole Blijlevens²  Sylvia van Deuren²  Ellen Keizer²  Jacqueline Loonen²  Adriaan Penson²  Marieke J. H. Coenen³  Marloes Louwerens⁴  Hans Knoop⁵  Andrica C. H. de Vries⁶  Eline van Dulmen-den Broeder⁷  Martha Grootenhuis⁸  Margriet van der Heiden-van der Loo⁹  Tom Heskes^1,10  Judith G. M. Rosmalen^1,11  Saskia M. F. Pluijm^1,12  Birgitta A. B. Versluys^1,12  Leontien C. M. Kremer^1,12  Marry M. van den Heuvel-Eibrink^1,12  Wim J. E. Tissing^1,12  Helena J. H. van der Pal^1,12  Sebastian Neggers^1,12 

[1] Department of Dentistry, Radboud Institute for Health Sciences, Radboud University Medical Center;Department of Hematology, Radboud University Medical Center;Department of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center;Department of Internal Medicine, Leiden University Medical Center;Department of Medical Psychology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public health research institute;Department of Pediatric Oncology, Erasmus Medical Center;Department of Pediatric Oncology/Hematology, Amsterdam University Medical Center;Department of Psychology, Princess Máxima Center for Pediatric Oncology;Dutch Childhood Oncology Group – Late Effects after Childhood Cancer (LATER) registry;Institute for Computing and Information Sciences, Radboud University;Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen;Princess Máxima Center for Pediatric Oncology;

关键词: Methodology;    Multivariable fatigue model;    Associated factors;    Cancer related fatigue;    Chronic fatigue;    Childhood Cancer survivors;   

DOI  :  10.1186/s12874-021-01298-7

来源: DOAJ

【 摘 要 】

Abstract Background A debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the methodology of the Dutch Childhood Cancer Survivor Late Effect Study on fatigue (DCCSS LATER fatigue study). The aim of the DCCSS LATER fatigue study is to examine the prevalence of and factors associated with CRF, proposing a model which discerns predisposing, triggering, maintaining and moderating factors. Triggering factors are related to the cancer diagnosis and treatment during childhood and are thought to trigger fatigue symptoms. Maintaining factors are daily life- and psychosocial factors which may perpetuate fatigue once triggered. Moderating factors might influence the way fatigue symptoms express in individuals. Predisposing factors already existed before the diagnosis, such as genetic factors, and are thought to increase the vulnerability to develop fatigue. Methodology of the participant inclusion, data collection and planned analyses of the DCCSS LATER fatigue study are presented. Results Data of 1955 CCS and 455 siblings was collected. Analysis of the data is planned and we aim to start reporting the first results in 2022. Conclusion The DCCSS LATER fatigue study will provide information on the epidemiology of CRF and investigate the role of a broad range of associated factors in CCS. Insight in associated factors for fatigue in survivors experiencing severe and persistent fatigue may help identify individuals at risk for developing CRF and may aid in the development of interventions.

【 授权许可】

Unknown