Methodology of the DCCSS later fatigue study: a model to investigate chronic fatigue in long-term survivors of childhood cancer

BMC Medical Research Methodology

Leontien C. M. Kremer¹  Ewald Bronkhorst²  Ellen Keizer³  Nicole Blijlevens³  Adriaan Penson³  Sylvia van Deuren³  Jacqueline Loonen³  Marieke J. H. Coenen⁴  Marloes Louwerens⁵  Hans Knoop⁶  Andrica C. H. de Vries⁷  Eline van Dulmen-den Broeder⁸  Martha Grootenhuis⁹  Margriet van der Heiden-van der Loo^1,10  Tom Heskes^1,11  Judith G. M. Rosmalen^1,12  Birgitta A. B. Versluys^1,13  Helena J. H. van der Pal^1,13  Saskia M. F. Pluijm^1,13  Sebastian Neggers^1,14  Marry M. van den Heuvel-Eibrink^1,15  Wim J. E. Tissing^1,16 

[1] Department Pediatric Oncology, Emma Children’s Hospital, University of Amsterdam, Amsterdam, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;Department of Dentistry, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands;Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands;Department of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands;Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands;Department of Medical Psychology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Public health research institute, Amsterdam, Netherlands;Department of Pediatric Oncology, Erasmus Medical Center, Rotterdam, The Netherlands;Department of Pediatric Oncology/Hematology, Amsterdam University Medical Center, Amsterdam, The Netherlands;Department of Psychology, Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;Dutch Childhood Oncology Group – Late Effects after Childhood Cancer (LATER) registry, Utrecht, The Netherlands;Institute for Computing and Information Sciences, Radboud University, Nijmegen, The Netherlands;Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;Department of Medicine, section Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;Department of Pediatric Oncology, Erasmus Medical Center – Sophia Children’s Hospital, Rotterdam, The Netherlands;Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands;Department of Pediatric Oncology/Hematology, Beatrix Children’s Hospital/University of Groningen/University Medical Center Groningen, Groningen, The Netherlands;

关键词: Methodology;    Multivariable fatigue model;    Associated factors;    Cancer related fatigue;    Chronic fatigue;    Childhood Cancer survivors;   

DOI  :  10.1186/s12874-021-01298-7

来源: Springer

【 摘 要 】

BackgroundA debilitating late effect for childhood cancer survivors (CCS) is cancer-related fatigue (CRF). Little is known about the prevalence and risk factors of fatigue in this population. Here we describe the methodology of the Dutch Childhood Cancer Survivor Late Effect Study on fatigue (DCCSS LATER fatigue study). The aim of the DCCSS LATER fatigue study is to examine the prevalence of and factors associated with CRF, proposing a model which discerns predisposing, triggering, maintaining and moderating factors. Triggering factors are related to the cancer diagnosis and treatment during childhood and are thought to trigger fatigue symptoms. Maintaining factors are daily life- and psychosocial factors which may perpetuate fatigue once triggered. Moderating factors might influence the way fatigue symptoms express in individuals. Predisposing factors already existed before the diagnosis, such as genetic factors, and are thought to increase the vulnerability to develop fatigue. Methodology of the participant inclusion, data collection and planned analyses of the DCCSS LATER fatigue study are presented.ResultsData of 1955 CCS and 455 siblings was collected. Analysis of the data is planned and we aim to start reporting the first results in 2022.ConclusionThe DCCSS LATER fatigue study will provide information on the epidemiology of CRF and investigate the role of a broad range of associated factors in CCS. Insight in associated factors for fatigue in survivors experiencing severe and persistent fatigue may help identify individuals at risk for developing CRF and may aid in the development of interventions.

【 授权许可】

CC BY