Did the COVID-19 Pandemic Increase the Incidence of Acute Macular Neuroretinopathy?

Journal of Clinical Medicine

Flore Salviat¹  Sophie Bonnin¹  Ramin Tadayoni¹  Elise Boulanger¹  Cherif Titah¹  Amélie Duvilliers¹  Georges Azar¹  Catherine Vignal Clermont¹  Sabine Derrien¹  Anthony Manassero¹  Rabih Hage¹  Vivien Vasseur¹  Selim Farès¹  Aude Couturier¹  Martine Mauget-Faÿsse¹  Francine Behar-Cohen²  Céline Faure³ 

[1] Clinical Investigative Platform Department, Adolphe de Rothschild Foundation, 75019 Paris, France;Ophthalmology Department, OphtalmoPôle, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, AP-HP, Université de Paris, 75014 Paris, France;Ramsay Générale de Santé, Private Hospital Saint Martin, 14000 Caen, France;

关键词: acute macular neuroretinopathy;    AMN;    COVID-19;    SARS-CoV-2;    retina;    OCT angiography;   

DOI  :  10.3390/jcm10215038

来源: DOAJ

【 摘 要 】

Background: Acute macular neuroretinopathy (AMN) is an increasingly diagnosed disorder associated with several diseases. The aim of this study was to report the incidence of AMN cases diagnosed during the 2020 coronavirus disease 2019 (COVID-19) pandemic year in a French hospital, and to describe their different forms. Methods: All patients diagnosed between 2019 and 2020, in Paris Rothschild Foundation Hospital, with AMN, paracentral acute middle maculopathy (PAMM) and multiple evanescent white dot syndrome (MEWDS) were retrospectively collected using the software Ophtalmoquery^® (Corilus, V1.86.0018, 9050 Gand, Belgium). Systemic and ophthalmological data from AMN patients were analyzed. Results: Eleven patients were diagnosed with AMN in 2020 vs. only one patient reported in 2019. The incidence of AMN significantly increased from 0.66/100,000 visits in 2019 to 8.97/100,000 visits in 2020 (p = 0.001), whereas the incidence of PAMM and MEWDS remained unchanged. Four (36%) of these AMN patients were tested for COVID-19 and received positive polymerase chain reaction (PCR) tests. Conclusions: The incidence of AMN cases increased significantly in our institution in 2020, which was the year of the COVID-19 pandemic. All AMN-tested patients received a positive COVID PCR test, suggesting a possible causative link. According to the different clinical presentations, AMN may reflect different severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pathogenic mechanisms.

【 授权许可】

Unknown