The Effects of Natural Products and Environmental Conditions on Antimicrobial Resistance

Molecules

Yujie Zhou¹  Saeed Ahmed²  Boyu An³  Guyue Cheng³  Cuirong Wu³  Lulu Huang³  Junhong Huang³  Yufeng Gu³ 

[1] College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, China;Department of Biological Sciences, National University of Medical Sciences, Rawalpindi 46000, Pakistan;MOA Laboratory for Risk Assessment of Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan 430070, China;

关键词: antimicrobial resistance;    co-selection;    antimicrobial peptides;    heavy metal;    microbial volatile compounds;    stress factors;   

DOI  :  10.3390/molecules26144277

来源: DOAJ

【 摘 要 】

Due to the extensive application of antibiotics in medical and farming practices, the continued diversification and development of antimicrobial resistance (AMR) has attracted serious public concern. With the emergence of AMR and the failure to treat bacterial infections, it has led to an increased interest in searching for novel antibacterial substances such as natural antimicrobial substances, including microbial volatile compounds (MVCs), plant-derived compounds, and antimicrobial peptides. However, increasing observations have revealed that AMR is associated not only with the use of antibacterial substances but also with tolerance to heavy metals existing in nature and being used in agriculture practice. Additionally, bacteria respond to environmental stresses, e.g., nutrients, oxidative stress, envelope stress, by employing various adaptive strategies that contribute to the development of AMR and the survival of bacteria. Therefore, we need to elucidate thoroughly the factors and conditions affecting AMR to take comprehensive measures to control the development of AMR.

【 授权许可】

Unknown