The Pharmacological Potential of Nonribosomal Peptides from Marine Sponge and Tunicates

Frontiers in Pharmacology

Alok Adholeya¹  Sunil Kumar Deshmukh¹  Shivankar Agrawal¹ 

[1] The Energy and Resources Institute;

关键词: Pharmacology;    Marine Natural Products;    sponge;    Marine ecosystem;    tunicates;    Non-ribosomal peptides;   

DOI  :  10.3389/fphar.2016.00333

来源: DOAJ

【 摘 要 】

Marine biodiversity is recognized by a wide and unique array of fascinating structures. The complex associations of marine microorganisms, especially with sponges, bryozoans, and tunicates, make it extremely difficult to define the biosynthetic source of marine natural products or to deduce their ecological significance. Marine sponges and tunicates are important source of novel compounds for drug discovery and development. Majority of these compounds are nitrogen containing and belong to non-ribosomal peptide (NRPs) or mixed polyketide–NRP natural products. Several of these peptides are currently under trial for developing new drugs against various disease areas, including inflammatory, cancer, neurodegenerative disorders and infectious disease. This review features pharmacologically active NRPs from marine sponge and tunicates based on their biological activities.

【 授权许可】

Unknown