Role of Honey in Advanced Wound Care

Molecules

Letícia M. Estevinho¹  Miguel Sousa Dias¹  José María Fresno²  Patricia Combarros-Fuertes²  María Eugenia Tornadijo²  Jorge A. Saraiva³  Carlos A. Pinto³  Hana Scepankova³ 

[1] CIMO, Mountain Research Center, Polytechnic Institute of Bragança, Campus Santa Apolónia, 5301-855 Bragança, Portugal;Department of Food Hygiene and Technology, Faculty of Veterinary Science, Campus de Vegazana, University of León, 24071 León, Spain;LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal;

关键词: honey;    wound-healing;    antioxidant;    antimicrobial;    hydrogels;    dermal repair;   

DOI  :  10.3390/molecules26164784

来源: DOAJ

【 摘 要 】

Honey is a natural product rich in several phenolic compounds, enzymes, and sugars with antioxidant, anticarcinogenic, anti-inflammatory, and antimicrobial potential. Indeed, the development of honey-based adhesives for wound care and other biomedical applications are topics being widely investigated over the years. Some of the advantages of the use of honey for wound-healing solutions are the acceleration of dermal repair and epithelialization, angiogenesis promotion, immune response promotion and the reduction in healing-related infections with pathogenic microorganisms. This paper reviews the main role of honey on the development of wound-healing-based applications, the main compounds responsible for the healing capacity, how the honey origin can influence the healing properties, also highlighting promising results in in vitro and in vivo trials. The challenges in the use of honey for wound healing are also covered and discussed. The delivery methodology (direct application, incorporated in fibrous membranes and hydrogels) is also presented and discussed.

【 授权许可】

Unknown