Malaria Journal | |
Artemether-lumefantrine to treat malaria in pregnancy is associated with reduced placental haemozoin deposition compared to quinine in a randomized controlled trial | |
关键词:
Malaria in pregnancy;
Placental malaria;
Artemisinin-based combination therapy;
Quinine;
Artemether-lumefantrine;
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DOI : 10.1186/1475-2875-11-150 | |
来源: DOAJ |
【 摘 要 】
Abstract
Background
Data on efficacy of artemisinin-based combination therapy (ACT) to treat
Methods
Women attending antenatal clinics with weekly screening and positive blood smears by microscopy were eligible to participate in the trial and were followed to delivery. Placental haemozoin deposition and inflammation were assessed by histology. To determine whether AL was associated with increased haemozoin clearance, population haemozoin clearance curves were calculated based on the longitudinal data.
Results
Of 152 women enrolled in each arm, there were 97 and 98 placental biopsies obtained in the AL and quinine arms, respectively. AL was associated with decreased rates of moderate to high grade haemozoin deposition (13.3%
Conclusions
Placental haemozoin deposition was decreased in the AL arm demonstrating a relationship between pharmacological properties of drug to treat antenatal malaria and placental pathology at delivery. Histology may be considered an informative outcome for clinical trials to evaluate malaria control in pregnancy.
Trial registration
REGISTRY:
【 授权许可】
Unknown