Ring distortion reactions directly alter the core ring systems of small molecules and can lead to striking changes in molecular structure. Strategic application of ring distortion reactions to complex molecules, such as natural products, is an effective method for the generation of compounds that exhibit significant molecular complexity, but possess vastly different molecular structures. The compounds produced by this complexity to diversity approach are advantageous starting points for the discovery of new biologically active compounds, as they possess a level of molecular complexity found in approved drugs but lacking in other screening collections used in drug discovery.The chapters herein emphasize the utility of ring distortion reactions for modifying complex molecules and assert the potential of ring distortion as strategy for the synthesis of complex and diverse small molecules. Chapter 1 defines the different methods of ring distortion and demonstrates how these reactions can be employed for the selective modification of complex molecules. Chapter 2 focuses on the application of ring distortion reactions to the cinchona alkaloid natural product quinine towards the creation of a collection of complex and diverse small molecules. Chapter 3 details the ring distortion of the terpene natural product abietic acid and details strategies for the synthesis of derivative libraries from the products of ring distortion. Chapter 4 describes on the ring distortion of the terpene natural product pleuromutilin and the discovery of a pleuromutilin-derived compound with anticancer activity.
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Chemical diversification of the natural products quinine, abietic acid and pleuromutilin by ring distortion
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